9/11/2023 0 Comments Gram negative rods blood culturePerformance Standards for Antimicrobial Susceptibility Testing. Clinical and Laboratory Standards Institute. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Clinical problems posed by multiresistant nonfermenting gram-negative pathogens. Life-threatening Pseudomonas aeruginosa infections in patients with human immunodeficiency virus infection. Kielhofner M, Atmar RL, Hamill RJ, Musher DM. Identifcation and Characterization of Non Fermenters From Clinical Specimens. Identication of nonfermenting Gram-negative bacteria of clinical importance by an oligonucleotide array. Siou CS, Mario V, Lenie D, Yu FW, Ya, LC, Tsung CC. Mandell’s principles and practice of infectious diseases. In: Mandell GL, Bennet JE, Dolin R, editors. Bloodstream infections caused by antibiotic-resistant gram-negative bacilli: risk factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Kang CI, Kim SH, Park WB, Lee KD, Kim HB, Kim EC, et al. Philadelphia: Lippincott - Raven Publishers. Colour Atlas and textbook of Diagnostic Microbiology. Koneman E, Allen S, Janda W, Schreckenberger P, Winn W. Mechanisms of resistance to beta-lactams in some common Gram-negative bacteria causing nosocomial infections. Suárez CJ, Lolans K, Villegas MV, Quinn JP. How bad are bacteremia and sepsis? Outcomes in a cohort with suspected bacteremia. Leibovici L, Greenshtain S, Cohen O, Mor F, Wysenbeek AJ. Improved antibiotic stewardship and strict infection control measures especially hand washing need to be implemented to prevent emergence and spread of multidrug resistant NFGNB in health care settings. The most effective drugs were colistin and tigecycline.Ĭonclusions: This study underlines the need to identify NFGNB in tertiary care hospitals and to monitor their susceptibility pattern to guide the clinician for better care and management of patients. Most of the non -fermenters were multi drug resistant showing a high level of antibiotic resistance to most of the first- and second-line drugs. (95) followed by Pseudomonas aeruginosa (11), Burkholderia cepacia (09) Sternotrophomonas maltophilia (03) and Sphingomonas sp. Results: A total of 120 NFGNB were identified out of which the most common non-fermenters isolated were Acinetobacter sp. Blood culture was done by automated blood culture system, (BacT/Alert) and identification and antibiotic susceptibility of non-fermenting gram negative bacilli was done by VITEK2 Compact System. All samples were processed according to standard microbiological procedures. Methods: A total of 3016 blood samples were received in the Department of Microbiology during the study period. The aim of this study was to assess frequency and antibiotic susceptibility pattern of non-fermenting gram-negative rods isolated from blood culture of patients. High intrinsic resistance of NFGNB to antimicrobial compounds makes the treatment of BSIs caused by them difficult and expensive. Department of Microbiology, Government Medical College, Srinagar, Jammu and Kashmir, Indiaĭepartment of Microbiology,Government Medical College, Srinagar, IndiaĪcinetobacter sp, Antibiotic susceptibility, Nosocomial pathogens, Non-fermenters Abstractīackground: Non-fermenting Gram-negative bacilli (NFGNB) are emerging as important causes of blood stream infections (BSI) and they are a major cause of morbidity and mortality worldwide.
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